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һDNAȫϢ

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2017-12-26 22:00:10 | ʾȫ¥ |Ķģʽ

ִĹ鵵޷ϢХȻ˸Ĵ𰸡

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DNAδ洢

Ӣ˹ŷϢоEBI鳤Nick Goldman˵DNAбݵ뷨ǴһЦʼġ

2011216Goldmanڵ¹һҾƵУһЩϢѧ̸ͬνеĻкݴ浽DNAСǵãʱѧǶԴͳ㼼ijɱ;ԸеdzɥǿʼÿƻõƷЦ˼ʲô谭ʹDNA洢Ϣ

ЦֹˡGoldmanඥʱ̡

ȷڹ洢оƬжȡдݷ棬DNA洢洢΢뼶ʱ߶Ŀ˹ϳضģʽDNAַҪСʱݣҪʱȥʹòָϢDNAĻ뵽һۿϸСϢ洢ĴܶȣDNAܳԽ˹輸ڳڹ鵵˵

Goldman䣬ʱŲͽֽԲھưʼ뷨Ҫʵָ뷨ҪЩʲôоԱĹÿ100һ1DNAϳɺͲ⽫ʹģݴ洢ȫɿǿҵһЧĴܷǼⲢķʽϢ뵽һԣҹ۽Goldmanҵ˷

EBIͬEwan Birney뷨ʵңѾɹʹDNAĵɯʿǵʮʫ·¡һ롱ݽеһ֡ѧGeorge ChurchݣţѧŶӣƳһDNAʾ739ǧֽڣKBEBIDNAļֱ20167£΢ͻʢٴѧоԱоԾ200ֽڣMB

ͳĴ洢ʲdzԶ֮

µʵʹDNAΪ洢ʵȤԶԶ˻飺һѹսͳеͼƬYouTubeƵڿ£2020꣬ȫֵݽﵽԼ44ǧֽڣGB2013ʮ2040һеĶԼʱʵķʽ洢磬ڼеоƬ浵Ԥڶ10 100΢оƬ衣

ҲΪʲôٱݵõĿǰʽŴԭ֮һýϢԱȹܼĶٶҪöࡣȻڻʢDC鱨߼оĿIARPAļ񾭿ѧDavid Markowitzָ ַdz֮ ˵ 'ŴһӵаֽڣʮֽڣĻʲôӡ һĽҪ10ԪʵĽԼ10ϵʱάҪߵĵMarkowitz˵ݴ洢DZЩеҪϢԱܼװ뵽󳦸˾ĻУôֻҪԼһDNAͿĴ洢

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ҪʵDZ򵥡DNAԳΪͳ洢ľ֮ǰоԱò˷սDNAпɿıϢֻûҪϢʹַ㹻Ѹ١

ǣӭЩսŬڼӿ졣뵼о˾SRCDurhamɵһᡪоƬҵ֧֣طDNA洢оGoldman BirneyӢоһDNA洢ƻһ˾ǵо4·ݣIARPASRCٰһѧͲҵоԱֻᣬIBM˾ֱооԱ

SRCκϯѧVictor Zhirnov˵

ʮһֱѰҳԽݹ鵵

ǺġǣDNAǿĺѡ֮һܻᷢ

ڼ

һϸ滮10ĸDNAԵJoe Davis1988ԹѧоԱDz뵽󳦸˾еDNAн35λһ5 7ʱ1Ӧڰض0ӦأγһնĴŮԵĻ档

Davis Churchʵң2011ʼ̽DNAݴ洢ѧоСϣӦóڽͺϳDNAijɱΪѧ˲ijɱChurch201111Sri KosuriڼǴѧɼͻѧרYuan GaoڰͶĦݵԼս˹ѧ˸֤ʵ顣оСʹDNAбһ659 kb汾飨Churchͬ׫дÿַһֶһַõַָ˲ƬӦΰţݡ0ͨʻऽб룬Ʊ1ऱʾŶӽʱȡ⣬ںдʺͰवֵظӵһʹַ۵졣ûϸϵĴÿַĶƷṩࡣˣַУKosuriChurchGao22󡪡ɿݴ洢Զ

EBIͬʱGoldmanBirneyǵͬҲDNAַǵ739 KBݴ洢аһͼASCIIıƵļWatsonCrick PDFı־ġDNA˫ṹΪ˱ظԴEBI쵼Ŷʹһӵķһ漰Ʊ10൱012ȻDzתеDNAÿһ֣ԱڶȡпܵСͨص100ַ25תƣEBIѧҲ֤ĸ汾ÿ25-IJ֣ڴͱ˴˶ա

յĽǣǻʧȥ25е2ɵǣļWatsonCrickIJļȻЩ˵GoldmanDNADZΪһ˵ġڵݴ洢⡪ֻҪٵ洢Ϊ˺ʲôdzڣָ2013顪һڶ700000Ĺͷн˵ģû˻һӲ̡ʮû˻ŴŴҪһȫĸƷ һǿԵõЩDNAдĶͿ԰һѨڵ֮ǰԲù

һ˵

ֿѾ˼ѧLuis CezeԻʢٴѧKarin Straussڻʢ٣׵ɵ΢оԺԴ2013ιӢʱGoldmanEBIStrauss˵DNAܶȣȶԺͳʹǺ˷ܡǷػʢٺStraussCeze뻪ʢٴѧĺGeorg SeeligʼоǵҪע֮һһҪȱ㡪ԶԶԽDNAڴĴԡʹñ׼򷽷ڲе£ûа취ԼκһݣÿһDNAҪȡȴͳļڴ鷳ͳļڴȡֻȡһûҪݡ

³ŶٿĻϸоԱʼǵDNAȡ΢СȻʹþۺøӦPCRȷַƷԱȡݡƷɢʹòǰķ죬ˣ׼ȷС黹һľ֯ʾݱΪEBIأһɿ

΢ ʢٴѧоԱʾ洢151 KBͼһһַУһЩʹEBIķһЩʹǵ·롣DzEBIķȡֻèϤԺͿͨõһҪֶĶȡҲʹǵ·ȡϤԺͼƬûзκδ

ѧ뻯ѧ

ŵѧķУļѧOlgica MilenkovicͬѾһʷͬȷǿдݡǵķ洢ΪDNAַ˶еַСоԱЩַѡ񡢷ŴʹPCR༭CRISPR Cas9дַ

ַĶУͬʱ˴ҲҪ㹻IJͬԷֹڳִʱ򱻻ǵаʶͰ󶨵Էȡ˼ǿ㣩µķ۵⡣Milenkovic˵ʼʱʹüΪĺӵЩԵĶ ŶѾѧʽȡͶܼḶ́ʹܹٵһֱ뷽

Kosuri˵DNAݴ洢սǺϳɷӵĹģٶȡɣԸ뷨ֹۡڹѧʵУ700kbʹ1000Ҳ700ףһCDȫݹ鵵ⷢζٴ洢PBϢⲢDzܵģKosuri˵DZʶĽĹģϰ򱶡

Markowitzͬⲻһ׵¡ռλһ30Ļѧ̣ӵÿҪ400ϵʱ䡣Ȼʹõķ˵ʮڵIJַͬԲзʽдٶȲ㹻졣ͬʱĵֵƵַ

һҪǺϳDNAijɱռEBIʵ12660Ԫ98%ֻռ2%ƻ2003ɣɱ˶򱶡KosurižҲͬϳDNAĽչ˵Ժ׵70˵гܽ70˵Ļ顱ϣɱһЩƿƻHGPwriteChurchһĿɵġĻüƻּںϳһ飺2332ڸȾɫԡʹHGPwriteɹˣKosuri˵ֻ0.75 GBϢٺϳʵݴ洢սͻԵμ穡

Zhirnov˵ۺϳɱԵˮƽǼ¡ΪʲôɱߣⲢûиԭ򡣡

£΢оһڵľٴ룬ڴҪ󣬼Twist BiosciencesݣɽһDNAϳ˾1000ַStraussͬ˵һֱʹõַƶǵȡ洢0.2GBϸڻδݱõ100еȨԣ100Ŀͼݿ⡣ȻúϳսHGP-writeҪС Strauss ǿڴ洢Ծ250塣

˵ʱһǴDNAļ⣬DNAƵķΧ̻ﱻϣʵںܶطжˡѧϰһΰ뷨

Goldmanģһܵ顣ǵĹǣҪ100000ĸĽʹͣΪǷdzŵģȻȥıֲܱ֤ÿһÿµĶȡͶڻѧʲô⡣ֻҪԵһ¡

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